The museum complex, adjacent to the church of Saints Jacopo and Filippo at the center of the medieval village of Certaldo, grows on the Oratory of the Company of the Precious Blood of Jesus, formerly dedicated to the Santissima Annunziata, to the former convent rooms, including the cell of Beata Giulia, the cloister, the garden and the basement.

The entrance is located in the small square, once a cemetery dedicated to the conventual burial. The museum was inaugurated on June 30th 2001, set up as part of the Piccoli Grandi Musei project, promoted by the suppressed Florentine Superintendence for the Museum Pole and Historical-Artistic Heritage, financed by the Fondazione CR di Firenze with the support of the Region of Tuscany, to create an integrated museum system with the other entities in the Lower Valdelsa and Florentine areas: from the Museum of the Collegiate Church of Empoli to those of Castelfiorentino, Montespertoli and Tavarnelle Valdelsa, including the Sacred Mount of San Vivaldo, in the municipality of Gambassi Terme, the Jerusalem in miniature where each chapel houses sculptural groups in glazed terracotta by Della Robbia, the Buglioni workshop and Agnolo di Polo.

These museums have ensured the cultural heritage of the territory over time, the expression of centuries-old faith and religiosity, protection and valorization through interconnected itineraries capable of making it accessible to an increasingly vast and more interested public.

Not only a museum project for the narration of a history of uninterrupted artistic creativity from the churches of the Vicariate of Certaldo, but also an opportunity to promote the works located in the Propositura di San Tommaso in Borgo, where they had been repaired after their withdrawal from the 1963 Art in Valdelsa Exhibition set up in the Vicariate Palace of Certaldo and largely restored by the Uffizi Restoration Cabinet and the Opificio delle Pietre Dure.